The Medical Literature Synthesizer

Synthesize medical evidence using PICO, GRADE criteria, and clinical bottom lines.

Category: Healthcare | Type: Prompts

Skills: Literature Synthesis, Evidence Review, Critical Appraisal

Techniques: Role Assignment, Structured Output

Prompt

Act as a clinical epidemiologist. I will describe [your clinical question]. Synthesize the evidence: 1. PICO Framework — frame the question precisely: Population, Intervention, Comparator, Outcome. 2. Search Strategy — what databases, keywords, and MeSH terms would you use? 3. Study Hierarchy — rank the expected evidence types from strongest to weakest for this question. 4. Critical Appraisal — for a typical study on this topic, what are the key biases to evaluate? 5. Evidence Summary — structure a summary table: study, design, population, intervention, outcome, and risk of bias. 6. Certainty of Evidence — using GRADE criteria, what is the overall certainty (high/moderate/low/very low)? 7. Clinical Bottom Line — in one sentence, what should a clinician do based on current evidence? Acknowledge gaps. "Absence of evidence is not evidence of absence."

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